The cyclic-AMP binding domain (CBD) is the central regulatory unit of exchange proteins activated by cAMP (EPAC).The CBD maintains EPAC in a state of auto-inhibition in the absence of the allosteric effector, cAMP.When cAMP binds to the CBD such auto-inhibition is released, leading to EPAC activation.It has been shown that a key feature of such cAM
DNA replication is initiated upon binding of "initiators" to origins of replication.In simian virus 40 (SV40), the core origin contains four pentanucleotide binding sites organized as pairs of inverted repeats.Here we describe the crystal structures of the origin binding domain (obd) of the SV40 large T-antigen (T-ag) both with and without Dresser
In the context of the 2024 presidential election campaign, the proliferation of memes as a medium of public and supporter expression has become increasingly prominent.Memes serve as a vehicle for political commentary, often reflecting public sentiment and opinion.However, a significant concern arises from the pervasive use of linguistic impolitenes